Artificial Organ Engineering.pdf
Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out. This book proposes a novel analysis of artificial organs based on the typical bottom-up approach used in process engineering. Starting from a description of the fundamental physico-chemical phenomena involved in the process, the whole system is rebuilt as an interconnected ensemble of elemental unit operations. Each artificial organ is presented with a short introduction provided by expert clinicians. Devices commonly used in clinical practice are reviewed and their performance is assessed and compared by using a mathematical model based approach. Whilst mathematical modelling is a fundamental tool for quantitative descriptions of clinical devices, models are kept simple to remain focused on the essential features of each process. Postgraduate students and researchers in the field of chemical and biomedical engineering will find that this book provides a novel and useful tool for the analysis of existing devices and, possibly, the design of new ones. This approach will also be useful for medical researchers who want to get a deeper insight into the basic working principles of artificial organs.
Maria Cristina Annesini is full professor of Chemical Engineering Fundamentals at the Department of Chemical Engineering Materials & Environment of the University "La Sapienza" of Rome and holds the chairs of "Transport Phenomena" and "Artificial Organ Engineering". She has a thirty-year experience in academic teaching and research and published about 100 papers, many of them referring to biotechnology and biomedical processes. Luigi Marrelli is full professor of Chemical Engineering Fundamentals. Until September 2009 he held the chair of "Chemical Reactors" at the Department of Chemical Engineering Materials & Environment of University of Rome "La Sapienza". Presently, he is Dean of the Engineering Faculty at the University "Campus Biomedico" of Rome where he holds the chairs of Artificial Organ Engineering and Molecular thermodynamics of biological systems. He has a forty-year experience on academic research and about 100 publications, many of them referring to biotechnology and biomedical processes. Vincenzo Piemonte is a postdoctoral fellow at the Department of Chemical Engineering of the University "La Sapienza" of Rome. His research activity is primarily focused on the study of transport phenomena in biomedical devices and reactor modelling. He has about 30 publications on chemical thermodynamics, kinetics and biomedical devices modelling. Presently, he is also academic tutor of Bioengineering at the University "Campus Biomedico" of Rome. Luca Turchetti is a postdoctoral fellow at the Department of Chemical Engineering of the University "La Sapienza" of Rome. His research activity is primarily focused on the study of transport phenomena in chemical reactors, biologic tissues and liver support devices. He authored and co-authored about 20 publications including chapters in books, conference papers and articles on international journals. Presently, he is also contract professor of Transport Phenomena at the University "Campus Biomedico" of Rome.
1. Diffusion.- 2. Mass transfer coefficient.- 3. Membrane operations.- 4. Adsorption.- 5. Bioreactors.