Principles and Methods of Toxicology.pdf

Principles and Methods of Toxicology.pdf


Based on the paradox that all things are poisonous at certain doses and the difference between poison and remedy is quantity, the determination of safe dosage forms the basis and focus of modern toxicology. Written by a team of experts with new editors joining Dr. Hayes, this sixth edition discusses basic toxicological principles, toxic agents, target organ toxicity, testing methods, and international regulatory requirements. New chapters cover advancements in nanotechnology and all chapters are updated to reflect the changing pace of research. Readers have access to an online version of the printed book.

Praise for the Previous Edition "... this is an excellent, very favourably-priced, all-round toxicology textbook suitable for all those new to the area and also invaluable for those longer in the tooth. Buy it and see for yourself what a great read it is!" -Paul Baldrick, Covance Laboratories Ltd, UK in BTS Newsletter, Issue 32 in 2008 "Wallace-Hayes has engaged over 90 distinguished investigators to contribute to this new edition. There is also a chapter dedicated to ... Statistics ... the information is presented in a logical sequence and it is an excellent reference source. I would recommend this book to any working one aiming to study in the area of safety sciences and it is a necessity for all those working in this area." -Shirley Price in BTS Newsletter, Issue 32 in 2008

Principles of Toxicology Harming and Helping Through Time: The History of Toxicology. The Use of Toxicology in the Regulatory Process. Metabolism: A Determinant of Toxicity. Toxicokinetics. Physiologically Based Pharmacokinetic and Toxicokinetic Models. Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology. The Toxicologic Assessment of Pharmaceutical and Biotechnology Products. Statistics for Toxicologists. Quantitative Extrapolations in Toxicology. The Practice of Exposure Assessment. Epidemiology for Toxicologists. Principles of Pathology for Toxicology Studies. The Information Infrastructure of Toxicology. Agents Foodborne Toxicants. Solvents and Industrial Hygiene. Crop Protection Chemicals: Mechanism of Action and Hazard Profiles. Metals, J.C. Merrill. Ionizing Radiation, L.G. Cockerham. Plant and Animal Toxins. Methods The Use of Laboratory Animals in Toxicology Research. Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods. Acute Toxicity and Eye Irritancy. Genetic Toxicology. Short-Term, Subchronic, and Chronic Toxicology Studies. Principles of Testing for Carcinogenic Activity. Principles of Clinical Pathology for Toxicology Studies. Dermatotoxicology. Inhalation Toxicology. Detection and Evaluation of Chemically Induced Liver Injury. Principles and Methods for Renal Toxicology. Gastrointestinal Toxicology. Principles and Methods of Cardiac Toxicology. Assessment of Male Reproductive Toxicity. Test Methods for Assessing Female Reproductive and Developmental Toxicology. Hormone Assays and Endocrine Function. Immunotoxicology: Effects of and Response to Drugs and Chemicals. Assessment of Behavioral Toxicity. Application of Isolated Organ Perfusion Techniques in Toxicology. Organelles as Tools in Toxicology. Analysis and Characterization of Enzymes and Nucleic Acids. Modern Instrumental Methods for Studying Mechanisms of Toxicology. Methods in Environmental Toxicology. Glossary. Index.


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