Hydroformylations: Fundamentals, Processes and Applications in Organic Synthesis.pdf

Hydroformylations: Fundamentals, Processes and Applications in Organic Synthesis.pdf
 

书籍描述

内容简介
Filling a gap in the market for an up-to-date work on the topic, this unique and timely book in 2 volumes is comprehensive in covering the entire range of fundamental and applied aspects of hydroformylation reactions. The two authors are at the forefront of catalysis research, and unite here their expertise in synthetic and applied catalysis, as well as theoretical and analytical chemistry. They provide a detailed account of the catalytic systems employed, catalyst stability and recovery, mechanistic investigations, substrate scope, and technical implementation. Chapters on multiphase hydroformylation procedures, tandem hydroformylations and other industrially applied reactions using syngas and carbon monoxide are also included. The result is a must-have reference not only for synthetic chemists working in both academic and industrial research, but also for theoreticians and analytical chemists.

作者简介
Armin Börner studied education and chemistry at the University of Rostock and completed his PhD thesis in the group of Prof. Dr. H. Kristen in 1984. Between 1984 and 1992 he was a scientific co-worker in the field of complex catalysis at the Academia of Science under Prof. Dr. H. Pracejus. After a postdoctoral term in the group of Prof. Dr. H. B. Kagan in Orsay, France, he relocated to the Max-Planck-Group for Asymmetric Catalysis in Rostock in 1993, where he was awarded his professorial research degree (habilitation) in 1995. Since 2000 he has been Professor of Organic Chemistry at the University of Rostock and head of a research department at the Leibniz-Institute for Catalysis (LIKAT) Rostock. His research focuses on applied homogeneous catalysis and he has published over 250 scientific papers, reviews, book chapters and patents. More than 15 catalytic processes and analytical tools which have been developed in his department are running in a technical scale or have been commercialized.

Robert Franke studied chemistry at Bochum University, Germany. He earned his doctorate degree in 1994 in the field of relativistic quantum chemistry under Prof. Dr. W. Kutzelnigg. After working for a period as a research assistant, he joined the process engineering department of the former Hüls AG in Germany, a predecessor company of Evonik Performance Materials GmbH, in 1998. He is now Director Innovation Management Hydroformylation. He was awarded his professorial research degree (habilitation) in 2002, since when he has taught at the University of Bochum. In 2011 he was made adjunct professor. His research focuses on homogeneous catalysis, process intensification, and computational chemistry. He has published over 150 scientific papers, reviews, book chapters and patents.


目录
INTRODUCTION

HOMOGENEOUSLY CATALYZED HYDROFORMYLATION
The Catalytic System

TECHNICAL IMPLEMENTATION OF HYDROFORMYLATION REACTIONS
Vessels and Conditions for Small Scale Reactions
Technical Set-Ups for Large Scale Reactions
Safety Issues
Influence of Metals, Ligands and Reaction Conditions on Activity and Regioselectivity
Solvents
Other Influences and Supporting Measurements (Microwaves, Irradiation)
Recovery of Homogeneous Catalysts and Separation of the Product

CATALYST DECOMPOSITION, ENEMIES OF LIGANDS AND CATALYSTS AND MEASURE AGAINST IT
General Aspects (Poison, Formation of Clusters)
Dormant Sites in the Catalytic Cycle (Sulfur Compounds, Enones, Butadienes, Alkynes)
Decomposition of Phosphines (Pathways, Products, Examples)
Decomposition of Ligands with P-O Bonds (Pathways, Products, Examples)
Decomposition of Carbene Ligands and Corresponding Catalysts

MECHANISTIC INVESTIGATIONS
Analytical Tools
Quantum Chemical Methods
The Mechanism

HYDROFORMYLATION IN MULTIPHASE CONDITIONS
General Aspects (Economic and Environmental Issues)
Biphasic Aqueous Phase Hydroformylations
Ionic Liquids
Reaction in CO2
Fluorous Solvents
Dendrimer-supported Catalysts
Supramolecular Catalysts, Self-assembling Catalysts
Catalysts Supported on Organic Polymers, Biopolymers or Inorganic Surfaces
Hydroformylation in Micro-Emulsions and Micellar Media

THE SUBSTRATES
Unfunctionalized Monoolefins
Functionalized Olefins and the Challenge of Substrate-directed Hydroformylation
Stereoselective Hydroformylations
Alkynes
Special Substrates

TANDEM-REACTIONS COVERING HYDROFORMYLATION
Isomerization Hydroformylation
Hydroformylation followed by Acetalization (Intramolecular, Intermolecular)
Hydroformylation followed by Hydrogenation
Hydroformylation followed by Amination (Intramolecular, Intermolecular)
Hydroaminomethylation (Intramolecular, Intermolecular;
Amines, Hydrazines)
Hydroformylation/Enantioselective Mannich Reactions
Hydroformylation followed by Cyclization Reactions (Cylodehydration)
Consecutive Hydroformylation-Aldol Reaction (Aldol Addition, Aldol Condensation, Aldol-Mukaiyama)
Tandem Enolboration /
Hydroformylation /
Aldol Addition
Consecutive Hydroformylation-Wittig Reaction
Consecutive Hydroformylation-Decarboxylative Knoevenagel Reaction
Hydroformylation-Ene Reaction
Hydroformylation-Alkylation

OTHER METAL CATALYZED REACTIONS WITH CO
Carbonylation of 2-Aryl-2-Oxazolines

OTHER REACTIONS WITH SYNGAS
Hydroformylation of Epoxides
Hydroformylation of Formaldehyde
Homologation of Alcohols

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