The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria.pdf

The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria.pdf


This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases.

•    Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death
•    Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments
•    Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field
•    Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders


Valentin Gribkoff is the former Chief Scientific Officer and Senior Vice President of Discovery Research at Knopp Neurosciences as well as a scientific consultant for pharmaceutical companies. He is currently a Visiting Research Scientist in the Department of Medicine at Yale University School of Medicine and a Founding Member of the Northwoods Group, a Biotech Consultant/Development group. He co-edited the book Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels (Wiley 2009) and is Series Editor for the Wiley Series on Neuropharmacology.

Elizabeth Jonas is an Associate Professor at the Departments of Internal Medicine, Section of Endocrinology, and Neurobiology at Yale University School of Medicine.

J. Marie Hardwick is the David Bodian Professor of Molecular Microbiology and Immunology at The Johns Hopkins Bloomberg School of Public Health.


Section I: Mitochondrial Structure and Ion Channels

Chapter 1: Mitochondrial Permeability Transition: Look from a Different Angle
N. Brustovetsky

Chapter 2: The mitochondrial permeability transition pore, the c-subunit of the F1FO ATP synthase, cellular development and synaptic efficiency
E.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian

Chapter 3: Mitochondrial channels in neurodegeneration
P.M. Peixoto, K.W. Kinnally and Evgeny Pavlov

Chapter 4: Mitochondrial Ca2+ Transport in the Control of Neuronal Functions: Molecular and Cellular Mechanisms
Y.M. Usachev

Section II: Control of Mitochondrial Signaling Networks

Chapter 5: AMP-activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection

P. Weisova, S. Pfeiffer and J.H.M. Prehn

Chapter 6: HDAC6: a molecule with multiple functions in neurodegenerative diseases
Y. Yan and R. Jiao

Chapter 7: Neuronal Mitochondrial Transport
A.L. Knight, Y. Chen, T. Sun and Z.H. Sheng

Chapter 8: Mitochondria in Control of Hypothalamic Metabolic Circuits
C.M. Nasrallah and T.L. Horvath

Chapter 9: Mitochondria Anchored at the Synapse
G.A. Spirou, D. Jackson and G.A. Perkins

Section III: Defective Mitochondrial Dynamics and Mitophagy

Chapter 10: Neuronal mitochondria are different: relevance to neurodegenerative disease

S.B. Berman and J.M. Hardwick

Chapter 11: PINK1 as a Sensor for Mitochondrial Function: Dual Roles
E.K. Steer, M.K. Dail and C.T. Chu

Chapter 12: A get-together to tear it apart: the mitochondrion meets the cellular turnover machinery
G.L. McLelland and E.A. Fon

Chapter 13: Mitochondrial involvement in neurodegenerative dementia
L. Bonanni, V. Frazzini, A. Thomas and M. Onofrj

Section IV: Mitochondria-Targeted Therapeutics and Model Systems

Chapter 14: Neuronal Mitochondria as a Target for the Discovery and Development of New Therapeutics
V.K. Gribkoff

Chapter 15: Mitochondria as a Therapeutic Target for Alzheimer’s disease
C.H.L. Hung, S.S.Y. Chung, S.M.Y. Lee and R.C.C. Chang

Chapter 16: Mitochondria in Parkinson Disease
G. Arena and E.M. Valente

Chapter 17: Therapeutic Targeting of Neuronal Mitochondria in Brain Injury
H.M. Yonutas, E.D. Hall and P.G. Sullivan

Chapter 18: The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapies
D. Soiferman and A. Saada


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